Human Connectome Project (HCP) — Disease Cohorts

Preprocessed and derived diffusion MRI connectomics resources from Human Connectome Project (HCP)–aligned disease cohorts.
These datasets provide derived files only (e.g., .fib, .gqi.fz, .qsdr.fz) that are ready for tractography and connectome analyses in DSI Studio and related tools.

NDA note: Per NDA policy, raw MRI data are not redistributed here. After consultation with the NDA program lead, derived data (e.g., FIB/FZ) may be shared publicly.
For other data types, request access directly through NDA. Once you have an approved Data Use Agreement (DUA), contact us and we can provide a link to SRC files where available.

Overview

This repository aggregates HCP-style disease cohorts processed into DSI Studio–compatible connectomics derivatives.
Each cohort uses HCP-aligned acquisition and/or processing wherever possible, enabling:

Typical assets include:

Raw MRI and detailed clinical data remain under NDA, institutional, or project-specific governance.

Visual Field Loss (VFL)

Release tag: vfl
Title: Changes in Visual Cortical Connectivity Following Central Visual Field Loss

Macular degeneration (MD) cohort processed with HCP-compatible pipelines to study visual cortical plasticity following central visual field loss.

Highlights

Download (Linux / macOS — bash)

curl -s https://api.github.com/repos/data-hcp/disease/releases/tags/vfl | jq -r '.assets[].browser_download_url' | xargs -n1 -P4 curl -LO

Download (Windows PowerShell 5.x)

(Invoke-RestMethod "https://api.github.com/repos/data-hcp/disease/releases/tags/vfl").assets | ForEach-Object { Invoke-WebRequest $_.browser_download_url -OutFile (Split-Path $_.browser_download_url -Leaf) }

Treatment-Resistant Depression (TRD)

Release tag: trd Title: Perturbation of the Treatment-Resistant Depression (TRD) Connectome by Fast-Acting Therapies

Longitudinal and cross-sectional TRD cohort with ECT, ketamine, and total sleep deprivation interventions, aligned to HCP normative references.

Highlights

Download (Linux / macOS — bash)

curl -s https://api.github.com/repos/data-hcp/disease/releases/tags/trd | jq -r '.assets[].browser_download_url' | xargs -n1 -P4 curl -LO

Download (Windows PowerShell 5.x)

(Invoke-RestMethod "https://api.github.com/repos/data-hcp/disease/releases/tags/trd").assets | ForEach-Object { Invoke-WebRequest $_.browser_download_url -OutFile (Split-Path $_.browser_download_url -Leaf) }

Human Connectome Project for Early Psychosis (EP)

Release tag: ep Title: Human Connectome Project for Early Psychosis

Early psychosis cohort acquired with HCP Lifespan Prisma protocols at Boston and Indianapolis, extending HCP methodology into severe mental illness.

Highlights

Download (Linux / macOS — bash)

curl -s https://api.github.com/repos/data-hcp/disease/releases/tags/ep | jq -r '.assets[].browser_download_url' | xargs -n1 -P4 curl -LO

Download (Windows PowerShell 5.x)

(Invoke-RestMethod "https://api.github.com/repos/data-hcp/disease/releases/tags/ep").assets | ForEach-Object { Invoke-WebRequest $_.browser_download_url -OutFile (Split-Path $_.browser_download_url -Leaf) }

Epilepsy Connectome Project (ECP)

Release tag: ecp Title: Epilepsy Connectome Project (ECP)

Temporal Lobe Epilepsy (TLE) vs. healthy controls, combining multimodal imaging and MEG for large-scale epilepsy connectomics.

Highlights

Download (Linux / macOS — bash)

curl -s https://api.github.com/repos/data-hcp/disease/releases/tags/ecp | jq -r '.assets[].browser_download_url' | xargs -n1 -P4 curl -LO

Download (Windows PowerShell 5.x)

(Invoke-RestMethod "https://api.github.com/repos/data-hcp/disease/releases/tags/ecp").assets | ForEach-Object { Invoke-WebRequest $_.browser_download_url -OutFile (Split-Path $_.browser_download_url -Leaf) }

BANDA: Connectomes Related to Anxiety & Depression

Release tag: banda Title: BANDA: Connectomes Related to Anxiety & Depression

Boston Adolescent Neuroimaging of Depression and Anxiety (BANDA) project: adolescent cohort targeting RDoC constructs of acute threat/fear and reward/prediction error.

Highlights

Download (Linux / macOS — bash)

curl -s https://api.github.com/repos/data-hcp/disease/releases/tags/banda | jq -r '.assets[].browser_download_url' | xargs -n1 -P4 curl -LO

Download (Windows PowerShell 5.x)

(Invoke-RestMethod "https://api.github.com/repos/data-hcp/disease/releases/tags/banda").assets | ForEach-Object { Invoke-WebRequest $_.browser_download_url -OutFile (Split-Path $_.browser_download_url -Leaf) }

Dimensional Connectomics of Anxious Misery (AM)

Release tag: am Title: Dimensional Connectomics of Anxious Misery

RDoC-inspired cohort focusing on Negative Valence System (NVS) constructs, especially Loss and Sustained Threat, in adults with “anxious misery” syndromes.

Highlights

Download (Linux / macOS — bash)

curl -s https://api.github.com/repos/data-hcp/disease/releases/tags/am | jq -r '.assets[].browser_download_url' | xargs -n1 -P4 curl -LO

Download (Windows PowerShell 5.x)

(Invoke-RestMethod "https://api.github.com/repos/data-hcp/disease/releases/tags/am").assets | ForEach-Object { Invoke-WebRequest $_.browser_download_url -OutFile (Split-Path $_.browser_download_url -Leaf) }

Licenses

Licensing follows each cohort’s original terms:

Each dataset directory includes license notes and, when applicable, links back to the original project pages.

Citations

When using these datasets:

  1. Cite the original disease cohort publications (VFL, TRD, EP, ECP, BANDA, AM) and their DOIs.
  2. Cite HCP, ACCESS, and supercomputing allocations CIS200026, MED230052 where applicable.
  3. If you use derivatives from this repository, please add:

“Derived diffusion MRI datasets were prepared by the Pittsburgh Fiber Data Hub (data-hcp/disease).”

Check individual dataset documentation for any additional citation or acknowledgment requirements.

Disclaimer