The Cancer Imaging Archive (TCIA) Collections

The Cancer Imaging Archive (TCIA) hosts de-identified cancer imaging datasets, organized by disease, modality, or research focus. Most collections share imaging in DICOM, sometimes accompanied by clinical, genomic, and expert annotation.

This repository provides curated, analysis-ready NIfTI derivatives for selected TCIA brain tumor collections.
Where possible, diffusion MRI derivatives (SZ / GQI / QSDR) are provided in formats compatible with DSI Studio.
Raw TCIA DICOM archives remain on TCIA servers; only derived files are mirrored here.

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UPenn-GBM — Advanced MRI, Clinical, Genomics & Radiomics

Release tag: upenn-gbm
Source: University of Pennsylvania Glioblastoma (UPenn-GBM) TCIA Collection

This collection provides multi-parametric MRI, clinical outcomes, tumor segmentations, and genomic features for de novo glioblastoma (GBM).

Included data

• Imaging
  • T1w, T2w, FLAIR, contrast-enhanced T1w
  • Skull-stripped, co-registered NIfTI volumes
• Segmentations
  • Tumor subregions (expert-corrected): enhancing, non-enhancing, edema
• Non-imaging (via TCIA)
  • Clinical outcomes
  • Genomics
  • Radiomics features
• Applications
  • Tumor segmentation benchmarking
  • Radiogenomics
  • Progression modeling and survival prediction

License

CC BY 4.0

Citation

Bakas S. et al., Scientific Data (2022) 9:453
The University of Pennsylvania glioblastoma (UPenn-GBM) cohort: Advanced MRI, clinical, genomics, & radiomics.

Linux / macOS — bash download

curl -s https://api.github.com/repos/data-nih/tcia/releases/tags/upenn-gbm | jq -r '.assets[].browser_download_url' | xargs -n1 -P4 curl -LO

Windows PowerShell 5.x download

(Invoke-RestMethod "https://api.github.com/repos/data-nih/tcia/releases/tags/upenn-gbm").assets | ForEach-Object { Invoke-WebRequest $_.browser_download_url -OutFile (Split-Path $_.browser_download_url -Leaf) }

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UCSF-PDGM — Preoperative Diffuse Glioma MRI

Release tag: ucsf-pdgm Source: UCSF Preoperative Diffuse Glioma MRI (TCIA)

This dataset contains preoperative MRI for 501 adult patients with WHO grade II–IV diffuse gliomas, including advanced diffusion and perfusion imaging.

Included data

• Cohort

  • 501 subjects
  • WHO grade II–IV
  • Genomic markers: IDH, MGMT, 1p/19q

• Imaging

  • 3D T2, 3D T2/FLAIR
  • SWI
  • DWI + 55-direction HARDI
  • Pre/post-contrast T1w
  • 3D ASL perfusion

• Segmentations

  • Enhancing tumor
  • Non-enhancing / necrotic tumor
  • FLAIR hyperintensity (edema)
  • Radiologist-refined BraTS-ensemble AI segmentations

• Applications

  • AI segmentation
  • Radiogenomics (IDH, MGMT prediction)
  • Comparative glioma research (vs. BraTS, TCGA-GBM, UPenn-GBM)

License

CC BY 4.0

Citation

Calabrese, E. et al. (2022). The University of California San Francisco Preoperative Diffuse Glioma MRI (UCSF-PDGM). TCIA. DOI: 10.7937/tcia.bdgf-8v37

Linux / macOS — bash download

curl -s https://api.github.com/repos/data-nih/tcia/releases/tags/ucsf-pdgm | jq -r '.assets[].browser_download_url' | xargs -n1 -P4 curl -LO

Windows PowerShell 5.x download

(Invoke-RestMethod "https://api.github.com/repos/data-nih/tcia/releases/tags/ucsf-pdgm").assets | ForEach-Object { Invoke-WebRequest $_.browser_download_url -OutFile (Split-Path $_.browser_download_url -Leaf) }

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Licensing and Use

• All derivatives follow the original TCIA collection licenses (mostly CC BY 4.0).

• Users must comply with:

  • TCIA data usage and citation requirements
  • Citations of the primary publications for each dataset
• When using curated derivatives from this repository, please add:

“Derived imaging files were curated via the Pittsburgh Fiber Data Hub (data-nih/tcia) from TCIA collections.”

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Notes

• This repository does not include the original DICOM archives (hosted on TCIA).
• NIfTI and diffusion derivatives are provided for convenience and downstream analysis (tractography, radiomics, segmentation research).
• Users should perform their own QC and methodological validation before scientific reporting.